Sequence-based association analyses on X chromosome in six dairy cattle breeds

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Sanchez, M, P | Escouflaire, C | Baur, A | Hozé, C | Capitan, A | Fritz, S | Boichard, D

Edité par CCSD -

International audience. Genomic evaluations in cattle are commonly based on effects of autosomal SNPs, the X chromosome (BTAX) being generally excluded because of its hemizygous state in males. We estimate here the effects of imputed sequence variants of BTAX in six dairy breeds and for 11 complex traits related to milk production, milk composition, mastitis resistance, fertility and stature. We detected QTL in almost all breeds and for almost all traits. They were distributed throughout BTAX and explained between 0.1 and 5.2% of the total phenotypic variance of the trait. In each of these QTL, we identified genes (GPC3, SEPTIN6, ZC3H12B, COL4A6, IDS,SLC16A2, MIR363, HS6T2, MAMLD1, COL4A6, DGKK, DDX3X, GPC3, ERCC6L, FRMPD4, ENOX2, KLHL13, HMGB3, and CDKL5) for which the functional link with the studied traits remains to be established. We therefore show here the importance of BTAX in the genetic determinism of complex traits in dairy cattle

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