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Evaluation of the role of endothelin in aortic stenosis

Archive ouverte | Levesque, T. | CCSD

International audience. IntroductionCalcified aortic stenosis (AS) is the most common acquired valvulopathy for which there is still no pharmacological treatment. Endothelin-1 (ET-1) is not only a powerful vasoconst...

Cardiovascular consequences of chronic kidney disease, impact of modulation of epoxyeicosatrienoic acids. Conséquences cardiovasculaires de l’insuffisance rénale chronique, intérêt d’une modulation des acides époxyeicosatriénoïques

Archive ouverte | Hamzaoui, M. | CCSD

International audience. Cardiovascular events are more prevalent in chronic kidney disease than in the general population, being the main cause of morbi-mortality. The physiopathology explaining this association rem...

Blocking Interleukin-1β transiently limits left ventricular dilation and reduces cardiac lymphangiogenesis during pressure-overload in mice

Archive ouverte | Heron, C. | CCSD

Blocking pro-inflammatory pathways, e.g. the inflammasome or interleukin (IL)-1β, is a promising therapeutic approach in heart failure (HF). We hypothesized that IL-1β may regulate cardiac lymphangiogenesis in response to chronic ...

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