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Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension

Archive ouverte | Baron, Morgane | CCSD

International audience. The G-protein-coupled receptor accessory protein MRAP2 is implicated in energy control in rodents, notably via the melanocortin-4 receptor1. Although some MRAP2 mutations have been described ...

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Archive ouverte | Saeed, Sadia | CCSD

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Archive ouverte | Meulebrouck, Sarah | CCSD

International audience. Functional genetics has identified drug targets for metabolic disorders. Opioid use impacts metabolic homeostasis, although mechanisms remain elusive. Here, we explore the OPRD1 gene (encodin...

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