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Prevalence of sexual dimorphism in mammalian phenotypic traits

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Karp, Natasha | Mason, Jeremy | Beaudet, Arthur | Benjamini, Yoav | Bower, Lynette | Braun, Robert | Brown, Steve | Chesler, Elissa | Dickinson, Mary | Flenniken, Ann | Fuchs, Helmut | Hrabe de Angelis, Martin | Gao, Xiang | Guo, Shiying | Greenaway, Simon | Heller, Ruth | Herault, Yann | Justice, Monica | Kurbatova, Natalja | Lelliott, Christopher | Lloyd, K | Mallon, Ann-Marie | Mank, Judith | Masuya, Hiroshi | Mckerlie, Colin | Meehan, Terrence | Mott, Richard | Murray, Stephen | Parkinson, Helen | Ramirez-Solis, Ramiro | Santos, Luis | Seavitt, John | Smedley, Damian | Sorg-Guss, Tania | Speak, Anneliese | Steel, Karen | Svenson, Karen | Wakana, Shigeharu | West, David | Wells, Sara | Westerberg, Henrik | Yaacoby, Shay | White, Jacqueline

Edité par CCSD ; Nature Publishing Group -

The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.

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