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EGFR as a potential therapeutic target for a subset of muscle-invasive bladder cancers presenting a basal-like phenotype

Archive ouverte | Rebouissou, Sandra | CCSD

International audience. A subtype of aggressive human muscle-invasive bladder cancer expresses basal epithelial markers and is sensitive to EGFR inhibition in preclinical models.

A Meta-Analysis of the Relationship between FGFR3 and TP53 Mutations in Bladder Cancer

Archive ouverte | Neuzillet, Yann | CCSD

International audience. TP53 and FGFR3 mutations are the most common mutations in bladder cancers. FGFR3 mutations are most frequent in low-grade low-stage tumours, whereas TP53 mutations are most frequent in high-g...

A Novel Epigenetic Phenotype Associated With the Most Aggressive Pathway of Bladder Tumor Progression

Archive ouverte | Vallot, Céline | CCSD

International audience. Background: Epigenetic silencing can extend to whole chromosomal regions in cancer. There have been few genome-wide studies exploring its involvement in tumorigenesis.Methods: We searched for...

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