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SARS-CoV-2 NSP1 induces mRNA cleavages on the ribosome

Archive ouverte | Tardivat, Yann | CCSD

International audience. In severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the non-structural protein NSP1 inhibits translation of host mRNAs by binding to the mRNA entry channel of the ribosome and, t...

The viral protein NSP1 acts as a ribosome gatekeeper for shutting down host translation and fostering SARS-CoV-2 translation

Archive ouverte | Tidu, Antonin | CCSD

SARS-CoV-2 coronavirus is responsible for Covid-19 pandemic. In the early phase of infection, the single-strand positive RNA genome is translated into non-structural proteins (NSP). One of the first proteins produced during viral ...

Correlated sequence signatures are present within the genomic 5'UTR RNA and NSP1 protein in coronaviruses

Archive ouverte | Sosnowski, Piotr | CCSD

International audience. The 5’UTR part of coronavirus genomes plays key roles in the viral replication cycle and the translation of the viral mRNAs. The first 75‐80 nucleotides, also called the leader sequence, are ...

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