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Analysis of the immune component of colorectal cancers and its potential impact on therapeutic strategies. Analyse de la composante immunitaire des cancers colorectaux et de son impact potentiel sur les stratégies thérapeutiques

Archive ouverte | El Sissy, Carine | CCSD

In this work, I analyzed the quality of the immune infiltrate of locally advanced rectal cancer (LARC) and showed that an adaptation of the Immunoscore test to diagnostic biopsies (ISB: tumor infiltration in T cells CD3+ and CD8+)...

Acquired and genetic drivers of C3 and C5 convertase dysregulation in C3 glomerulopathy and immunoglobulin-associated MPGN

Archive ouverte | Roquigny, Julia | CCSD

International audience. Dysregulation of the alternative pathway of complement plays a central role in the pathophysiology of C3 glomerulopathy (C3G). Various autoimmune and genetic factors targeting the alternative...

Delayed Generalized Necrotic Purpuric Rash in a C6-deficient 12-year-old Girl Treated for Group W Meningococcal Disease.

Archive ouverte | Gaschignard, Jean | CCSD

International audience. We report an unusual case of generalized necrotic purpuric rash that started 48 hours after the initiation of effective third-generation cephalosporin therapy to treat Neisseria meningitidis ...

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