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Engineering of three-finger fold toxins creates ligands with original pharmacological profiles for muscarinic and adrenergic receptors

Archive ouverte | Fruchart-Gaillard, Carole | CCSD

International audience. Protein engineering approaches are often a combination of rational design and directed evolution using display technologies. Here, we test ‘‘loop grafting,’’ a rational design method, on thre...

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Archive ouverte | Servent, Denis | CCSD

International audience. Muscarinic toxins isolated from the venom of Dendroaspis snakes may interact with a high affinity, large selectivity and various functional properties with muscarinic receptors. Therefore, th...

Structural model of ligand-G Protein-coupled Receptor (GPCR) complex based on experimental double mutant cycle data

Archive ouverte | Marquer, Catherine | CCSD

International audience. The snake toxin MT7 is a potent and specific allosteric modulator of the human M1 muscarinic receptor (hM1). We previously characterized by mutagenesis experiments the functional determinants...

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