Syracuse

The nonribosomal synthesis of diketopiperazines in tRNA-dependent cyclodipeptide synthase pathways

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Belin, Pascal | Moutiez, Mireille | Lautru, Sylvie | Seguin, Jérôme | Pernodet, Jean-Luc | Gondry, Muriel

Edité par CCSD ; Royal Society of Chemistry -

International audience. We review here work on the biosynthesis of diketopiperazines (DKPs), a large class of natural products with noteworthy biological activities, focusing on the biosynthetic pathways involving cyclodipeptide synthases (CDPSs), a newly defined family of enzymes. Distinct from nonribosomal peptide synthetases (NRPSs), the other family of enzymes synthesizing DKPs, CDPSs bridge the primary and secondary metabolic pathways by hijacking aminoacyl-tRNAs to produce DKPs. This review includes a comprehensive description of the state of the art for CDPS-dependent pathways, and highlights the ways in which this knowledge could be used to increase the diversity of natural DKPs by pathway engineering.

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