Overexpression of Annexin A1 Is an Independent Predictor of Longer Overall Survival in Epithelial Ovarian Cancer

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Manai, Maroua | Doghri, Raoudha | Finetti, Pascal | Mrad, Karima | Bouabsa, Rihab | Manai, Mohamed | Birnbaum, Daniel | Bertucci, François | Charfi, Lamia | Driss, Maha

Edité par CCSD ; International Institute of Anticancer Research (IIAR) -

International audience. Background: Epithelial ovarian cancer (EOC) is the major gynecological cause of cancer deaths. Annexin A1 (ANXA1) protein has been implicated in the aggressiveness of several cancer types.Materials and methods: This study retrospectively assessed ANXA1 expression in epithelial cells of 156 pre-chemotherapy EOC samples and 34 normal ovarian samples from patients treated at Salah Azaiez Institute. Using immunohistochemistry, ANXA1 expression was compared in normal versus cancer samples; correlations with clinicopathological features, including overall survival, were sought.Results: Fifty-two percent of tumor samples showed epithelial ANXA1 staining versus only 26% of normal samples (Fisher's exact test, p=0.00794). Epithelial ANXA1 expression was correlated with better overall survival in both univariate and multivariate analyses.Conclusion: The possible contribution of ANXA1 overexpression to EOC outcome may be relevant to therapeutic strategies.

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