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Human Dectin-1 is O-glycosylated and serves as a ligand for C-type lectin receptor CLEC-2

Archive ouverte | Haji, Shojiro | CCSD

International audience. C-type lectin receptors (CLRs) elicit immune responses upon recognition of glycoconjugates present on pathogens and self-components. While Dectin-1 is the best-characterized CLR recognizing β...

A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells.

Archive ouverte | Sakaguchi, Masanori | CCSD

International audience. In the subventricular zone of the adult mammalian forebrain, neural stem cells (NSCs) reside and proliferate to generate young neurons. We screened factors that promoted the proliferation of ...

A multi-omic atlas of human embryonic skeletal development

Archive ouverte | To, Ken | CCSD

International audience. Human embryonic bone and joint formation is determined by coordinated differentiation of progenitors in the nascent skeleton. The cell states, epigenetic processes and key regulatory factors ...

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