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An essential role for α4A-tubulin in platelet biogenesis

Archive ouverte | Strassel, Catherine | CCSD

International audience. During platelet biogenesis, microtubules (MTs) are arranged into submembranous structures (the marginal band) that encircle the cell in a single plane. This unique MT array has no equivalent ...

Mutations in the most divergent α‐tubulin isotype, α8‐tubulin, cause defective platelet biogenesis

Archive ouverte | Kimmerlin, Quentin | CCSD

International audience. Background: In the panel of genes commonly associated with inherited macrothrombocytopenia, an important fraction encodes key cytoskeletal proteins such as tubulin isotypes, the building bloc...

Functional properties of human platelets derived in vitro from CD34+ cells

Archive ouverte | Do Sacramento, Valentin | CCSD

International audience. The in vitro production of blood platelets for transfusion purposes is an important goal in the context of a sustained demand for controlled products free of infectious, immune and inflammato...

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