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Tenascin-C Promotes Tumor Cell Migration and Metastasis through Integrin alpha9beta1-Mediated YAP Inhibition

Archive ouverte | Sun, Zhen | CCSD

Tenascin-C is an extracellular matrix molecule that drives progression of many types of human cancer, but the basis for its actions remains obscure. In this study, we describe a cell-autonomous signaling mechanism explaining how t...

Tenascin-C increases lung metastasis by impacting blood vessel invasions

Archive ouverte | Sun, Zhen | CCSD

International audience

Counterbalancing anti-adhesive effects of Tenascin-C through fibronectin expression in endothelial cells.

Archive ouverte | Radwanska, Agata | CCSD

International audience. Cellular fibronectin (FN) and tenascin-C (TNC) are prominent development-and disease-associated matrix components with pro-and anti-adhesive activity, respectively. Whereas both are present i...

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