Results of Second Round Lung Cancer Screening by Low-Dose CT scan-French Cohort Study (DEP-KP80)

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Leleu, Olivier | Basille, Damien | Auquier, Marianne | Clarot, Caroline | Hoguet, Estelle | Baud, Mickael | Lenel, Sabrina | Milleron, Bernard | Berna, Pascal | Jounieaux, Vincent

Edité par CCSD ; Elsevier -

International audience. Lung cancer screening by LD CT scan demonstrated in prior studies a decrease in lung cancer mortality, as well as in overall mortality. The aim of our prospective multicentric study was to assess the implementation of three annual lung cancer screenings in a real-life setting in France. The results of the second round of our study showed the feasibility of this screening program in the general population and revealed that it would indeed be necessary to further optimize screening participation during the subsequent rounds by improving communication with the target population and the respective healthcare professionals. Introduction: Over the last few years, lung cancer screening by low-dose CT scan has demonstrated a decrease in lung cancer mortality. While this method has been in use since 2013 in the United States of America, no European country has yet implemented a systematic screening program. We hereby report the results from the second round of screening from a French cohort study. Patients and Methods: DEP KP80 is a prospective study evaluating lung cancer screening by means of three low-dose computer tomography (CT) scans at 1-year intervals in 1,307 participants, aged 55 to 74 years old, all smokers or former smokers, having quit within the last 15 years, with over 30 pack years. The results of the first round demonstrated it was possible to conduct effective screening in real-life situations. Results: Participation was lower in this second round than in the first (35.3% vs. 73.1%, P < .001). The rate of negative results was significantly higher and that of undetermined results lower than those produced in the first round. Overall, 75% of cancers revealed were Stage 1 and 87.5% benefitted from surgical treatment. The incidence of cancer in the second round was 2.43%. Conclusion: As with the first round, the results of this second round confirm the feasibility and efficacy of lung cancer screening. The lower participation rate for this second round is proof of the need to improve awareness among participants and healthcare professionals of the relevance of committing to an annual screening program.

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