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Kidney Transplant Recipients Carrying the CYP3A4*22 Allelic Variant Have Reduced Tacrolimus Clearance and Often Reach Supratherapeutic Tacrolimus Concentrations

Archive ouverte | Pallet, N. | CCSD

International audience. CYP3A4*22 is an allelic variant of the cytochrome P450 3A4 associated with a decreased activity. Carriers of this polymorphism may require reduced tacrolimus (Tac) doses to reach the target r...

Predictive Modeling of Tacrolimus Dose Requirement Based on High-Throughput Genetic Screening

Archive ouverte | Damon, C. | CCSD

International audience. Any biochemical reaction underlying drug metabolism depends on individual gene-drug interactions and on groups of genes interacting together. Based on a high-throughput genetic approach, we s...

[COVID-19 and organ transplantation, lessons from the national Registry of the Société Francophone de Transplantation]. COVID-19 et transplantation d’organes, les leçons du recensement national de la Société francophone de transplantation

Archive ouverte | Caillard, Sophie | CCSD

International audience. The Covid-19 pandemic hit the transplant world in March 2020. Teams quickly organized themselves to optimize the management of their immunocompromised patients and to progress in the knowledg...

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