Syracuse

Neurotoxic Concentration of Piperacillin during Continuous Infusion in Critically Ill Patients

Archive ouverte

Quinton, Marie-Charlotte | Bodeau, Sandra | Kontar, Loay | Zerbib, Yoann | Maizel, Julien | Slama, Michel | Masmoudi, Kamel | Lemaire-Hurtel, Anne-Sophie | Bennis, Youssef

Edité par CCSD ; American Society for Microbiology -

International audience. This retrospective cohort study included 53 patients admitted to the intensive care unit (ICU), with an average age of 69 years, without neurologic disorder before initiation of a continuous piperacillin infusion at the standard dose and who underwent piperacillin serum concentration monitoring. Among them, 23 developed a neurologic disorder for which the piperacillin causality was chronologically and semiologically suggestive. A concentration threshold of 157.2 mg/liter independently predicted neurotoxicity with 96.7% specificity and 52.2% sensitivity and may constitute a limitation when targeting less susceptible pathogens.

• Description
• Sujet/Public
• Outil
• Outil d'anticipation
• Mémoire et thèse
• Gestion