Afficher la couverture 'Toward a Consensus in the Repertoire of Hemocytes Identified in Drosophila | Cattenoz, Pierre' en grand format
/5

0 avis

Toward a Consensus in the Repertoire of Hemocytes Identified in Drosophila

Archive ouverte

Cattenoz, Pierre | Monticelli, Sara | Pavlidaki, Alexia | Giangrande, Angela

Edité par CCSD ; Frontiers media -

International audience. The catalog of the Drosophila immune cells was until recently limited to three major cell types, based on morphology, function and few molecular markers. Three recent single cell studies highlight the presence of several subgroups, revealing a large diversity in the molecular signature of the larval immune cells. Since these studies rely on somewhat different experimental and analytical approaches, we here compare the datasets and identify eight common, robust subgroups associated to distinct functions such as proliferation, immune response, phagocytosis or secretion. Similar comparative analyses with datasets from different stages and tissues disclose the presence of larval immune cells resembling embryonic hemocyte progenitors and the expression of specific properties in larval immune cells associated with peripheral tissues.

Suggestions

Du même auteur

An anti-inflammatory transcriptional cascade conserved from flies to humans

Archive ouverte | Pavlidaki, Alexia | CCSD

International audience. Innate immunity is an ancestral process that can induce pro-and anti-inflammatory states. A major challenge is to characterise the transcriptional cascades that modulate the response to chron...

Temporal specificity and heterogeneity of Drosophila immune cells

Archive ouverte | Cattenoz, Pierre | CCSD

International audience. Immune cells provide defense against non-self and have recently been shown to also play key roles in diverse processes such as development, metabolism, and tumor progression. The hetero-genei...

Early-wave macrophages control late hematopoiesis

Archive ouverte | Monticelli, Sara | CCSD

International audience. Macrophages constitute the first defense line against the non-self, but their ability to remodel their environment in organ development/homeostasis is starting to be appreciated. Early-wave m...

Chargement des enrichissements...