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Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2

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Marek, Martin | Ramos-Morales, Elizabeth | Picchi-Constante, Gisele, F A | Bayer, Theresa | Norström, Carina | Herp, Daniel | Sales-Junior, Policarpo, A | Guerra-Slompo, Eloise, P | Hausmann, Kristin | Chakrabarti, Alokta | Shaik, Tajith, B | Merz, Annika | Troesch, Edouard | Schmidtkunz, Karin | Goldenberg, Samuel | Pierce, Raymond, J | Mourão, Marina, M | Jung, Manfred | Schultz, Johan | Sippl, Wolfgang | Zanchin, Nilson, I T | Romier, Christophe

Edité par CCSD ; Elsevier Inc -

International audience. Highlights d Trypanosome histone deacetylases (HDACs) significantly diverge from human HDACs d T. cruzi class I HDACs tcDAC1 and tcDAC2 are essential to the parasite viability d tcDAC2 deacetylase activity can be inhibited by targeting its atypical active site d T. cruzi parasites can be targeted through a tcDAC2-specific inhibitor

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