Association of plasma YKL-40 with brain amyloid-β levels, memory performance, and sex in subjective memory complainers
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Vergallo, Andrea | Lista, Simone | Lemercier, Pablo | Chiesa, Patrizia A. | Zetterberg, Henrik | Blennow, Kaj | Potier, Marie-Claude | Habert, Marie-Odile | Baldacci, Filippo | Cavedo, Enrica | Caraci, Filippo | Dubois, Bruno | Hampel, Harald | Bakardjian, Hovagim | Benali, Habib | Bertin, Hugo | Bonheur, Joel | Boukadida, Laurie | Boukerrou, Nadia | Chiesa, Patrizia | Colliot, Olivier | Dubois, Marion | Epelbaum, Stéphane | Gagliardi, Geoffroy | Genthon, Remy | Houot, Marion | Kas, Aurélie | Lamari, Foudil | Levy, Marcel | Metzinger, Christiane | Mochel, Fanny | Nyasse, Francis | Poisson, Catherine | Revillon, Marie | Santos, Antonio | Andrade, Katia Santos | Sole, Marine | Surtee, Mohmed | de Schotten, Michel Thiebaut | Younsi, Nadjia | Afshar, Mohammad | Aguilar, Lisi Flores | Akman-Anderson, Leyla | Arenas, Joaquín | Ávila, Jesús | Babiloni, Claudio | Batrla, Richard | Benda, Norbert | Black, Keith L. | Bokde, Arun L.W. | Bonuccelli, Ubaldo | Broich, Karl | Cacciola, Francesco | Caruso, Giuseppe | Castrillo†, Juan | Ceravolo, Roberto | Corbo, Massimo | Corvol, Jean-Christophe | Cuello, Augusto Claudio | Cummings, Jeffrey L. | Depypere, Herman | Duggento, Andrea | Emanuele, Enzo | Escott-Price, Valentina | Federoff, Howard | Ferretti, Maria Teresa | Fiandaca, Massimo | Frank, Richard A. | Garaci, Francesco | Geerts, Hugo | Giacobini, Ezio | Giorgi, Filippo S. | Goetzl, Edward J. | Graziani, Manuela | Haberkamp, Marion | Hänisch, Britta | Herholz, Karl | Hernandez, Felix | Imbimbo, Bruno P. | Kapogiannis, Dimitrios | Karran, Eric | Kiddle, Steven J. | Kim, Seung H. | Koronyo, Yosef | Koronyo-Hamaoui, Maya | Langevin, Todd | Lehéricy, Stéphane | Llavero, Francisco | Lorenceau, Jean | Lucía, Alejandro | Mango, Dalila | Mapstone, Mark | Neri, Christian | Nisticò, Robert | O’bryant, Sid E. | Palermo, Giovanni | Perry, George | Ritchie, Craig | Rossi, Simone | Saidi, Amira | Santarnecchi, Emiliano | Schneider, Lon S. | Sporns, Olaf | Toschi, Nicola | Valenzuela, Pedro L. | Vellas, Bruno | Verdooner, Steven R. | Villain, Nicolas | Giudici, Kelly Virecoulon | Watling, Mark | Welikovitch, Lindsay A. | Woodcock, Janet | Younesi, Erfan | Zugaza, José L.
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CCSD ; Elsevier -
International audience.
Neuroinflammation, a key early pathomechanistic alteration of Alzheimer’s disease, may represent either a detrimental or a compensatory mechanism or both (according to the disease stage). YKL-40, a glycoprotein highly expressed in differentiated glial cells, is a candidate biomarker for in vivo tracking neuroinflammation in humans. We performed a longitudinal study in a monocentric cohort of cognitively healthy individuals at risk for Alzheimer’s disease exploring whether age, sex, and the apolipoprotein E ε4 allele affect plasma YKL-40 concentrations. We investigated whether YKL-40 is associated with brain amyloid-β (Aβ) deposition, neuronal activity, and neurodegeneration as assessed via neuroimaging biomarkers. Finally, we investigated whether YKL-40 may predict cognitive performance. We found an age-associated increase of YKL-40 and observed that men display higher concentrations than women, indicating a potential sexual dimorphism. Moreover, YKL-40 was positively associated with memory performance and negatively associated with brain Aβ deposition (but not with metabolic signal). Consistent with translational studies, our results suggest a potentially protective effect of glia on incipient brain Aβ accumulation and neuronal homeostasis.
