Case series of carbapenemase-producing Enterobacteriaceae osteomyelitis: Feel it in your bones

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Davido, B. | Noussair, L. | Saleh-Mghir, A. | Salomon, E. | Bouchand, F. | Matt, M. | Lawrence, C. | Bauer, T. | Herrmann, J.L. | Perronne, C. | Gaillard, J.L. | Rottman, M. | Dinh, A.

Edité par CCSD ; Elsevier -

International audience. Objectives: Limited data have been reported regarding osteomyelitis due to carbapenemase-producing Enterobacteriaceae (CPE), including co-infections with extended-spectrum β-lactamase (ESBL)-producing micro-organisms.Methods: We conducted a retrospective study in a reference centre for bone and joint infections from 2011 to 2019 among patients infected with CPE.Results: Nine patients (mean age 46.8 ± 16.6 years), including three with infected implants, were identified. Infections were mostly polymicrobial (n = 8/9), including Staphylococcus aureus (n = 6/9). CPE were mainly OXA-48-type, associated with ESBL-producing Enterobacteriaceae (n = 8/9), of which 5/9 isolates were Klebsiella pneumoniae. Control of the infection was achieved in seven cases.Conclusions: CPE osteomyelitides are essentially polymicrobial and fluoroquinolone-resistant infections, highlighting the need for efficient surgery with implant removal.

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