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Overlapping functions of SIX homeoproteins during embryonic myogenesis

Archive ouverte | Wurmser, Maud | CCSD

International audience. Four SIX homeoproteins display a combinatorial expression throughout embryonic developmental myogenesis and they modulate the expression of the myogenic regulatory factors. Here, we provide a...

A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes

Archive ouverte | dos Santos, Matthieu | CCSD

International audience. The contractile properties of adult myofibers are shaped by their Myosin heavy chain isoform content. Here, we identify by snATAC-seq a 42 kb super-enhancer at the locus regrouping the fast M...

Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle

Archive ouverte | Sakakibara, Iori | CCSD

International audience. AbstractBackgroundAdult skeletal muscles are composed of slow and fast myofiber subtypes which each express selective genes required for their specific contractile and metabolic activity. Six...

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