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Toxoplasmosis as an Early Complication of Allogeneic Hematopoietic Cell Transplantation

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Robin, Christine | Leclerc, Mathieu | Angebault, Cécile | Redjoul, Rabah | Beckerich, Florence | Cabanne, Ludovic | Foulet, Francoise | Pautas, Cécile | Toma, Andréa | Maury, Sébastien | Botterel, Francoise | Cordonnier, Catherine

Edité par CCSD ; Elsevier -

International audience. Among 419 consecutive allogeneic hematopoietic cell transplant recipients, we observed 17 (4.0%) cases of toxoplasmosis at a median time of day 45 (range, 6 to 322) after transplant. Seven of these 17 cases occurred before day 30 after transplant. Because of the lack of PCR screening and trimethoprim-sulfamethoxazole prophylaxis before engraftment, the diagnosis of toxoplasmosis was late, and 5 of these 7 patients died. Analyzing these cases, early Toxoplasma blood PCR screening, starting from transplant, is crucial.

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