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Oral metformin transiently lowers post-prandial glucose response by reducing the apical expression of sodium-glucose co-transporter 1 in enterocytes

Archive ouverte | Zubiaga, Lorea | CCSD

International audience. Highlights Metformin transiently reduces SGLT1 apical expression in enterocytes Metformin acutely reduces SGLT1-mediated enterocyte glucose uptake Oral metformin acutely reduces SGLT1-mediate...

Inter-Individual Heterogeneity of SGLT2 Expression and Function in Human Pancreatic Islets.

Archive ouverte | Saponaro, Chiara | CCSD

International audience. Studies implicating sodium–glucose cotransporter 2 (SGLT2) inhibitors in glucagon secretion by pancreatic α-cells reported controversial results. We hypothesized that interindividual heteroge...

Ten-Year Outcome of Islet Alone or Islet After Kidney Transplantation in Type 1 Diabetes: A Prospective Parallel-Arm Cohort Study

Archive ouverte | Vantyghem, Marie-Christine | CCSD

International audience. OBJECTIVE The long-term outcome of allogenic islet transplantation is unknown. The aim of this study was to evaluate the 10-year outcome of islet transplantation in patients with type 1 diabe...

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