Afficher la couverture 'Modeling patient-specific desaturation patterns in sleep apnea | Guerrero, Gustavo' en grand format
/5

0 avis

Modeling patient-specific desaturation patterns in sleep apnea

Archive ouverte

Guerrero, Gustavo | Le Rolle, Virginie | Loiodice, Corinne | Amblard, Amel | Pepin, Jean-Louis | Hernandez, Alfredo I

Edité par CCSD ; Institute of Electrical and Electronics Engineers -

International audience. OBJECTIVE: The physiological mechanisms involved in cardio-respiratory responses to sleep apnea events are not yet fully elucidated. A model-based approach is proposed to analyse the acute desaturation response to obstructive apneas. METHODS: An integrated model of cardio-respiratory interactions was proposed and parameters were identified, using an evolutionary algorithm, on a database composed of 107 obstructive apneas acquired from 10 patients (HYPNOS clinical study). Unsupervised clustering was applied to the identified parameters in order to characterize the phenotype of each response to obstructive apneas. RESULTS: A close match was observed between simulated oxygen saturation (SaO2) and experimental SaO2 in all identifications (median RMSE = 1.3892%). Two clusters of parameters, associated with different dynamics related to sleep apnea and periodic breathing were obtained. CONCLUSION AND SIGNIFICANCE: The proposed patient and event-specific model-based analysis provides understanding on specific desaturation patterns, consequent to apnea events, with potential applications for personalized diagnosis and treatment.

Suggestions

Du même auteur

Kinesthetic stimulation for obstructive sleep apnea syndrome: An “on-off” proof of concept trial

Archive ouverte | Hernandez, Alfredo | CCSD

International audience. Obstructive sleep apnea (OSA) occurs when the upper airway narrows or collapses due to the loss of upper airway muscle activation at sleep onset. This study investigated the effectiveness of ...

Prediction of response to cardiac resynchronization therapy using a multi-feature learning method

Archive ouverte | Gallard, Alban | CCSD

International audience. We hypothesized that a multiparametric evaluation, based on the combination of electrocardiographic and echocardiographic parameters, could enhance the appraisal of the likelihood of reverse ...

Modeling Patient-specific Apnea-bradycardia Patterns in Preterm Newborn

Archive ouverte | Duport, Orlane | CCSD

International audience. Objective: Preterm infants are particularly exposed to severe cardio-respiratory events, associating apnea with bradycardia and oxygen desaturation. A patient-specific and event-specific mode...

Chargement des enrichissements...