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Dynamic Functional Connectivity in Adolescence-Onset Major Depression: Relationships With Severity and Symptom Dimensions.

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Marchitelli, Rocco | Paillère-Martinot, Marie-Laure | Bourvis, Nadège | Guerin-Langlois, Christophe | Kipman, Amélie | Trichard, Christian | Douniol, Marie | Stordeur, Coline | Galinowski, André | Filippi, Irina | Bertschy, Gilles | Weibel, Sebastien | Granger, Bernard | Limosin, Frédéric | Cohen, David | Martinot, Jean-Luc | Artiges, Eric

Edité par CCSD ; Elsevier -

The spatial functional chronnectome is an innovative mathematical model designed to capture dynamic features in the organization of brain function derived from resting-state functional magnetic resonance imaging data. Measurements of dynamic functional connectivity have been developed from this model to quantify the brain dynamical self-reconfigurations at different spatial and temporal scales. This study examined whether two spatiotemporal dynamic functional connectivity quantifications were linked to late adolescence-onset major depressive disorder (AO-MDD), and scaled with depression and symptom severity measured with the Montgomery-Åsberg Depression Rating Scale.

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