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Lipophilic Conjugates for Carrier-Free Delivery of RNA Importable into Human Mitochondria

Archive ouverte | Dovydenko, Ilya | CCSD

International audience. Defects in human mitochondrial genome can cause a wide range of clinical disorders which still do not have efficient therapies. The natural pathway of small non-coding RNA import can be explo...

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Archive ouverte | Tonin, Yann | CCSD

Defects in mitochondrial genome can cause a wide range of clinical disorders, mainly neuromuscular diseases. Presently, no efficient therapeutic treatment has been developed against this class of pathologies. Because most of delet...

Modifications in Therapeutic Oligonucleotides Improving the Delivery

Archive ouverte | Dovydenko, Ilya | CCSD

International audience. Oligonucleotides are increasingly used in clinical applications. RNA-based therapeutics include inhibitors of mRNA translation, agents of RNA interference, ribozymes, and aptamers targeting v...

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