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Iatrogenic transmission of Alzheimer's disease: Evidence based on experimental inoculation of Alzheimer's brains into a primate
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Edité par CCSD ; Alzheimer's Association / Wiley -
International audience. Background: Epidemiologic data suggest that, in humans, iatrogenic administration of compounds (cadaver-sourced human growth hormone, dura mater graft) or cerebral surgeries with tools contaminated with Aβ and tau induce aggregated Aβ and possibly tau lesions. Aβ and tau lesions could thus be iatrogenically transmitted to humans. Several studies in mice have shown that experimental inoculation of amyloid and/or taupositive brain samples into transgenic (tg) mouse models overexpressing Aβ or tau promotes either Aβ or tau aggregation in the brain of the recipient animal. Unlike rodents, primates naturally express Aβ or tau under normal conditions and they have a biochemical and physical cerebral environment that is closer to that of humans than that of mice. The aim of this work was to evaluate the impact of human brain samples inoculations in the mouse lemur primates.
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