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Sulfated glycosaminoglycans mediate prion-like behavior of p53 aggregates

Archive ouverte | Iwahashi, Naoyuki | CCSD

International audience. Sulfated glycosaminoglycans (GAGs) such as heparan sulfate (HS) are heteropolysaccharides implicated in the pathology of protein aggregation diseases including localized and systemic forms of...

Impacts of cytoplasmic p53 aggregates on the prognosis and the transcriptome in lung squamous cell carcinoma

Archive ouverte | Nishitsuji, Kazuchika | CCSD

International audience. The tumor suppressor TP53 gene, the most frequently mutated gene in human cancers, produces the product tumor protein p53, which plays an essential role in DNA damage. p53 protein mutations m...

Cytoplasmic p53 aggregates accumulated in p53-mutated cancer correlate with poor prognosis

Archive ouverte | Iwahashi, Naoyuki | CCSD

International audience. Abstract Recent studies suggested that aggregates of mutant p53 proteins may propagate and impair normal p53 functioning in recipient cells. Our previous study showed that cancer cell-derived...

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