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Targeting Epigenetic Modifiers Can Reduce the Clonogenic Capacities of Sézary Cells

Archive ouverte | Chebly, Alain | CCSD

International audience. Seźary syndrome (SS) is an aggressive leukemic variant of cutaneous T-cell lymphomas (CTCL) in which the human Telomerase Reverse Transcriptase (hTERT) gene is reexpressed. Current available ...

Exploring hTERT promoter methylation in cutaneous T‐cell lymphomas

Archive ouverte | Chebly, Alain | CCSD

International audience

Epigenetic modulation of hTERT expression in cutaneous T-cell lymphomas. L'épigénétique comme modulateur de l'expression de hTERT dans les lymphomes T cutanés

Archive ouverte | Chebly, Alain | CCSD

Cutaneous T-lymphomas (CTCL) are telomerase-positive tumors expressing hTERT, in which neither amplification, nor rearrangement, nor promoter hotspot mutations can explain the re-expression of the gene. As the hTERT promoter is ri...

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