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Multi-feature clustering of CTCF binding creates robustness for loop extrusion blocking and Topologically Associating Domain boundaries

Archive ouverte | Chang, Li-Hsin | CCSD

International audience. Topologically Associating Domains (TADs) separate vertebrate genomes into insulated regulatory neighborhoods that focus genome-associated processes. TADs are formed by Cohesin-mediated loop e...

Of Dots and Stripes: The Morse Code of Micro-C Reveals the Ultrastructure of Transcriptional and Architectural Mammalian 3D Genome Organization

Archive ouverte | Chang, Li-Hsin | CCSD

International audience. Using Micro-C, Hsieh et al. (2020) and Krietenstein et al. (2020) investigated 3D chromatin folding in human and mouse cells at unprecedented resolution, to uncover ultra-fine-scale chromatin...

TADs and Their Borders: Free Movement or Building a Wall?

Archive ouverte | Chang, Li-Hsin | CCSD

International audience. The tridimensional (3D) organization of mammalian genomes combines structures from different length scales. Within this organization, Topologically Associating Domains (TADs) are visible in H...

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