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Nonhomologous recombination: bacterial transposons

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Guynet, Catherine | Siguier, Patricia | Chandler, Michael | Ton-Hoang, Bao

Edité par CCSD ; Elsevier -

International audience. Transposons, also called “jumping genes” are DNA fragments capable of moving/transposing from one locus to another within or between genomes. Transposons are ubiquitous and are present in all kingdoms of life. They can be present as variable portions of genomes, promote genome rearrangements and activate or turn off gene expression. In bacteria, they actively participate in horizontal gene transfer by sequestering and propagating genes such as resistance to antimicrobials, virulence and pathogenicity. Transposons employ DNA or RNA intermediates in their transposition pathways; bacteria harbor exclusively DNA transposons. Transposons are also classified in families depending on the types of transposase (enzymes which catalyze transposon mobility) they encode.

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