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Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin

Archive ouverte | Kotila, Tommi | CCSD

International audience. The ability of cells to generate forces through actin filament turnover was an early adaptation in evolution. While much is known about how actin filaments grow, mechanisms of their disassemb...

Structural basis of rapid actin dynamics in the evolutionarily divergent Leishmania parasite

Archive ouverte | Kotila, Tommi | CCSD

International audience. Abstract Actin polymerization generates forces for cellular processes throughout the eukaryotic kingdom, but our understanding of the ‘ancient’ actin turnover machineries is limited. We show ...

The advantages of microfluidics to study actin biochemistry and biomechanics

Archive ouverte | Wioland, Hugo | CCSD

International audience. The regulated assembly of actin filaments is essential in nearly all cell types. Studying actin assembly dynamics can pose many technical challenges. A number of these challenges can be overc...

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