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LKB1 Roles in the Liver. Etude du rôle de LKB1 dans le foie

Archive ouverte | Just, Pierre-Alexandre | CCSD

CTNNB1-Mutated hepatocellular carcinomas (HCC) share a specific polarity and metabolic phenotype without steatosis. We hypothesized that such phenotype could imply the tumor suppressor gene LKB1 that encodes for a multi-Task Ser/T...

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Archive ouverte | Moret, Sandrine | CCSD

International audience

LKB1 signaling is activated in CTNNB1 -mutated HCC and positively regulates β-catenin-dependent CTNNB1 -mutated HCC

Archive ouverte | Charawi, Sara | CCSD

International audience. CTNNB1‐mutated HCC. They were found to be well‐differentiated, almost never steatotic, and often cholestatic, with a microtrabecular or acinar growth pattern. Here, we investigated whether LK...

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