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Activation of primary sensory neurons by the topical application of capsaicin on the epidermis of a re-innervated organotypic human skin model.

Archive ouverte | Lebonvallet, Nicolas | CCSD

International audience. Using an ex vivo skin-nerve preparation, skin and nerve cells were reconstituted into a single unit and maintained in a nutrient medium bath until required experimentally. Our objective was t...

Effect of human skin explants on the neurite growth of the PC12 cell line.

Archive ouverte | Lebonvallet, Nicolas | CCSD

International audience. The skin is a densely innervated organ. After a traumatic injury, such as an amputation, burn or skin graft, nerve growth and the recovery of sensitivity take a long time and are often incomp...

Two-photon microscopy of dermal innervation in a human re-innervated model of skin.

Archive ouverte | Sevrain, David | CCSD

International audience. When skin is injured, innervation can be severely disrupted. The subsequent re-innervation processes are poorly understood notably because of the inability to image the full meandering course...

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