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HBV replication in primary macaque hepatocytes: crossing the species barrier towards a new small primate model

Archive ouverte | Lucifora, Julie | CCSD

International audience. The development of new anti-hepatitis B virus (HBV) therapies, especially immunotherapeutic approaches, has been limited by the lack of a primate model more accessible than chimpanzees. We ha...

Characterization of Pattern Recognition Receptor Expression and Functionality in Liver Primary Cells and Derived Cell Lines

Archive ouverte | Faure-Dupuy, Suzanne | CCSD

International audience. Different liver cell types are endowed with immunological properties, including cell-intrinsic innate immune functions that are important to initially control pathogen infections. However, a ...

Hepatitis D virus interferes with hepatitis B virus RNA production via interferon-dependent and -independent mechanisms

Archive ouverte | Lucifora, Julie | CCSD

International audience. Background & Aims: Chronic co-infection with hepatitis B and D viruses (HBV and HDV) leads to the most aggressive form of chronic viral hepatitis. Here, we aimed at elucidating the molecu...

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