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A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control

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Namineni, Sukumar | O'Connor, Tracy | Faure-Dupuy, Suzanne | Johansen, Pål | Riedl, Tobias | Liu, Kaijing | Xu, Haifeng | Singh, Indrabahadur | Shinde, Prashant | Li, Fanghui | Pandyra, Aleksandra | Sharma, Piyush | Ringelhan, Marc | Muschaweckh, Andreas | Borst, Katharina | Blank, Patrick | Lampl, Sandra | Neuhaus, Katharina | Durantel, David | Farhat, Rayan | Weber, Achim | Lenggenhager, Daniela | Kündig, Thomas | Staeheli, Peter | Protzer, Ulrike | Wohlleber, Dirk | Holzmann, Bernhard | Binder, Marco | Breuhahn, Kai | Assmus, Lisa Mareike | Nattermann, Jacob | Abdullah, Zeinab | Rolland, Maude | Dejardin, Emmanuel | Lang, Philipp | Lang, Karl | Karin, Michael | Lucifora, Julie | Kalinke, Ulrich | Knolle, Percy | Heikenwalder, Mathias

Edité par CCSD ; Elsevier -

International audience. Hepatic innate immune control of viral infections has largely been attributed to Kupffer cells, the liver-resident macrophages. However, hepatocytes, the parenchymal cells of the liver, also possess potent immunological functions in addition to their known metabolic functions. Owing to their abundance in the liver and known immunological functions, we aimed to investigate the direct antiviral mechanisms employed by hepatocytes.

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