Photo-induced graft-versus-host disease

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Hardy, Juliette | Marguery, Marie-Claude | Huynh, Anne | Borel, Cécile | Apoil, Pol-André | Lamant, Laurence | Tournier, Emilie | Alberto, Chloé | Pauwels, Céline | Thomas, Marianne | Mazereeuw Hautier, Juliette | Paul, Carle | Bulai Livideanu, Cristina

Edité par CCSD ; Wiley -

International audience. Overlap chronic graft-versus-host disease (GVHD) associates both features of acute and chronic GVHD. Trigger factors for chronic GVHD are unclear. We describe two patients who received allogenic haematopoietic stem-cell transplantation, and who later developed overlap chronic GVHD after sun exposure. Available data from in vivo investigations suggest ultraviolet B radiation (UVB) has a beneficial effect on acute and chronic GVHD. The role of sun irradiation as a trigger for isomorphic cutaneous GVHD has been rarely reported in the literature. Herein, we demonstrate for the first time, using repetitive broadband phototesting, that UVB triggers chronic GVHD.

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