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Biochemical, biophysical and structural study of proteins associated to human diseases : tcDAC2 and ADAT complex. Études biochimiques, biophysiques et structurales des protéines associées aux maladies humaines : tcDAC2 et le complexe ADAT

Archive ouverte | Ramos Morales, Elizabeth | CCSD

During my PhD thesis, I studied two proteins associated to human diseases: tcDAC2 and the ADAT complex.TcDAC2 is a histone deacetylase from the parasite Typanosoma cruzi which causes the Chagas disease. TcDAC2 is essential for T. ...

Structure–Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma mansoni ( Sm Sirt2)

Archive ouverte | Monaldi, Daria | CCSD

International audience. The only drug currently available for treatment of the neglected disease Schistosomiasis is Praziquantel, and the possible emergence of resistance makes research on novel therapeutic agents n...

Phenotypic Screening of Histone Deacetylase (HDAC) Inhibitors against Schistosoma mansoni

Archive ouverte | Hassan, Muhammad Murtaza | CCSD

Schistosomiasis is a prevalent yet neglected tropical parasitic disease caused by the Schistosoma genus of blood flukes. Praziquantel is the only currently available treatment, hence drug resistance poses a major threat. Recently,...

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