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Inhibitory signalling to the Arp2/3 complex steers cell migration

Archive ouverte | Dang, Irene | CCSD

International audience. Cell migration requires the generation of branched actin networks that power the protrusion of the plasma membrane in lamellipodia. The actin-related proteins 2 and 3 (Arp2/3) complex is the ...

Hybrid Structural Analysis of the Arp2/3 Regulator Arpin Identifies Its Acidic Tail as a Primary Binding Epitope

Archive ouverte | Fetics, Susan | CCSD

International audience. Arpin is a newly discovered regulator of actin polymerization at the cell leading edge, which steers cell migration by exerting a negative control on the Arp2/3 complex. Arpin proteins have a...

Inactivating negative regulators of cortical branched actin enhances persistence of single cell migration

Archive ouverte | Fokin, Artem, I | CCSD

International audience. The Rac1-WAVE-Arp2/3 pathway pushes the plasma membrane by polymerizing branched actin, thereby powering membrane protrusions that mediate cell migration. Here, using knock-down (KD) or knock...

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