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NS3 protease polymorphism and natural resistance to protease inhibitors in French patients infected with HCV genotypes 1–5

Archive ouverte | Vallet, Sophie | CCSD

International audience

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Archive ouverte | Vallet, Sophie | CCSD

International audience. Hepatitis C virus (HCV) protease inhibitor resistance-associated substitutions are selected during triple-therapy breakthrough. This multicenter quality control study evaluated the expertise ...

Natural non-homologous recombination led to the emergence of a duplicated V3-NS5A region in HCV-1b strains associated with hepatocellular carcinoma

Archive ouverte | Le Guillou-Guillemette, Hélène | CCSD

International audience. Background: The emergence of new strains in RNA viruses is mainly due to mutations or intra and inter-genotype homologous recombination. Non-homologous recombinations may be deleterious and a...

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