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Prevalence of cervical HPV infection, sexually transmitted infections and associated antimicrobial resistance in women attending cervical cancer screening in Mali
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International audience. Objectives: To assess sexually transmitted infections (STIs) prevalence, antimicrobial resistance and cervical lesions among women from Sikasso, Mali.Methods: HIV-infected (n=44) and HIV-uninfected (n=96) women attending cervical cancer screening were included. Human papillomavirus (HPV), Chlamydia trachomatis (CT), Mycoplasma genitalium (MG), Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV) detections were performed by PCR and herpes simplex virus (HSV-1/2) serological status by ELISA assays. Antibiotics-resistance tests were performed for MG and NG positives cases.Results. We evidenced a high prevalence of high-risk HPV (hrHPV) infection (63%), associated with cervical lesion in 7.5% of cases and an unusual hrHPV distribution with HPV31, HPV56 and HPV52 being the most prevalent. According to HIV-status, hrHPVs distribution was also different (HIV-positive: HPV35/31/51-52-56 and HIV-negative: HPV31/56/52). HSV-2 seroprevalence was 49%, and prevalence of other STIs as follow: CT: 4%, MG: 9%, NG: 1% and TV: 7%. Five out of 9 MG-positive specimens and the NG strains obtained were fluoroquinolone-resistant.Conclusions. Our results showed a high prevalence of hrHPV and fluoroquinolone-resistance in several NG and MG strains. Further studies are required to confirm these data in Mali and to improve prevention, screening and management of cervical cancer and others STIs in women.
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