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Analytical comparison of ELISA and mass spectrometry for quantification of serum hepcidin in critically ill patients

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Delaby, Constance | Vialaret, Jérôme | Hirtz, Christophe | Lefebvre, Thibaud | Herkert, Matthias | Puy, Hervé | Lasocki, Sigismond | Asfar, Pierre | Mercat, Alain | Gaillard, Thomas | Gergaud, Soizic | Sargentini, Cyrille | Geneve, Claire | Montravers, Philippe | Lefebvre, Thibault | Mercier, Grégoire | Nagot, Nicolas | Lehmann, Sylvain | Chanques, Gerald | Jaber, Samir | Asehnoune, Karim | Roquilly, Antoine | Dahyot-Fizelier, Claire | Mimoz, Olivier | Isslame, Sonia | Seguin, Philippe | Barbaz, Mathilde | Ferrandiere, Martine | Kerforne, Thomas | Peoc'H, Katell | Beloncle, François | Leger, Maxime | Rineau, Emmanuel | Marin, Gregory | Boisson, Matthieu | Launey, Yoann

Edité par CCSD ; Future Science -

International audience. Aim: To compare methods of quantifying serum hepcidin (based on MS and ELISA) and their ability to diagnose true iron deficiency anemia in critically ill patients. Materials & methods: Serum hepcidin was measured in 119 critically ill patients included in the HEPCIDANE clinical trial, using either an ultra-sensitive ELISA kit (from DRG) or two different MS methods. Results: The results show a good correlation between the different methods studied. The Bland–Altman analysis and the Kappa test for clinical groups show a good or very good agreement between the different tests. Conclusion: ELISA or MS show a satisfactory commutability to quantify serum hepcidin. This is of great importance for the determination of therapeutic strategies in iron deficiency.

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