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Axonal Targeting of the 5-HT1B Serotonin Receptor Relies on Structure-Specific Constitutive Activation

Archive ouverte | Carrel, Damien | CCSD

International audience. . By analogy to other axonal proteins, transcytotic delivery following spontaneous endocytosis from the somatoden-dritic membrane is expected to be essential for polarized distribution of axo...

Constitutive endocytic cycle of the CB1 cannabinoid receptor.

Archive ouverte | Leterrier, Christophe | CCSD

The CB1 cannabinoid receptor (CB1R) displays a significant level of ligand-independent (i.e. constitutive) activity, either when heterologously expressed in nonneuronal cells or in neurons where CB1Rs are endogenous. The present s...

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Archive ouverte | Thibault, Karine | CCSD

International audience. Chronic pain is a long-lasting debilitating condition that is particularly difficult to treat due to the lack of identified underlying mechanisms. Although several key contributing processes ...

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