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Comparison of the predictive accuracy of multiple definitions of cognitive impairment for incident dementia: a 20-year follow-up of the Whitehall II cohort study

Archive ouverte | Machado-Fragua, Marcos | CCSD

International audience. Studies generally use cognitive assessment done at one timepoint to define cognitive impairment in order to examine conversion to dementia. Our objective was to examine the predictive accurac...

Clinical, socioeconomic, and behavioural factors at age 50 years and risk of cardiometabolic multimorbidity and mortality: A cohort study

Archive ouverte | Singh-Manoux, Archana | CCSD

International audience. BACKGROUND: Multimorbidity is increasingly common and is associated with adverse health outcomes, highlighting the need to broaden the single-disease framework that dominates medical research...

The association of APOE ε4 with cognitive function over the adult life course and incidence of dementia: 20 years follow-up of the Whitehall II study

Archive ouverte | Gharbi-Meliani, Amin | CCSD

International audience. Abstract Background Approximately 25% of the general population carries at least one ε4 allele of the Apolipoprotein E ( APOE ε4), the strongest genetic risk factor for late onset Alzheimer’s...

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