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Inflammatory Markers During Early Treatment of Seroconverters in a Randomized Placebo-Controlled Trial of PrEP (ANRS-IPERGAY)

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Chawki, Sylvain | Charreau, Isabelle | Gabassi, Audrey | Carette, Diane | Cua, Eric | Cotte, Laurent | Pialoux, Gilles | Pintado, Claire | Meyer, Laurence | Chaix, Marie-Laure | Delaugerre, Constance | Molina, Jean-Michel

Edité par CCSD ; Oxford University Press -

International audience. HIV-related inflammation is associated with poor outcomes. We describe inflammatory biomarkers in 17 participants in a pre-exposure prophylaxis trial who seroconverted with very early initiation of antiretroviral therapy. Inflammation peaked at the time of HIV infection and returned to baseline within 6-12 months. Starting antiretroviral therapy very early could help mitigate long-lasting HIV-related inflammation.

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