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Allosteric Model of Maraviroc Binding to CC Chemokine Receptor 5 (CCR5)

Archive ouverte | Garcia-Perez, Javier | CCSD

International audience

A single-residue change in the HIV-1 V3 loop associated with maraviroc resistance impairs CCR5 binding affinity while increasing replicative capacity.

Archive ouverte | Garcia-Perez, Javier | CCSD

International audience. Maraviroc (MVC) is an allosteric CCR5 inhibitor used against HIV-1 infection. While MVC-resistant viruses have been identified in patients, it still remains incompletely known how they adjust...

CCR5 structural plasticity shapes HIV-1 phenotypic properties

Archive ouverte | Colin, Philippe | CCSD

International audience. CCR5 plays immune functions and is the coreceptor for R5 HIV-1 strains. It exists in diverse conformations and oligomerization states. We interrogated the significance of the CCR5 structural ...

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