The nature and identification of quantitative trait loci: a community’s view

Archive ouverte

Abiola, Oduola | Angel, Joe M. | Avner, Philip | Bachmanov, Alexander A. | Belknap, John K. | Bennett, Beth | Blankenhorn, Elizabeth P. | Blizard, David A. | Bolivar, Valerie | Brockmann, Gudrun A. | Buck, Kari J. | Bureau, Jean-François | Casley, William L. | Chesler, Elissa J. | Cheverud, James M. | Churchill, Gary A. | Cook, Melloni | C.Crabbe, John | Crusio, Wim E. | Darvasi, Ariel | Haan, Gerald De | Demant, Peter | Doerge, R. W. | Elliott, Rosemary W. | Farber, Charles R. | Flaherty, Lorraine | Flint, Jonathan | Gershenfeld, Howard | Gibson, John P. | Gu, Jing | Gu, Weikuan | Himmelbauer, Heinz | Hitzemann, Robert | Hsu, Hui-Chen | Hunter, Kent | Iraqi, Fuad A. | Jansen, Ritsert C. | Johnson, Thomas E. | Jones, Byron C. | Kempermann, Gerd | Lammert, Frank | Lu, Lu | Manly, Kenneth F. | Matthews, Douglas B. | Medrano, Juan F. | Mehrabian, Margarete | Mittleman, Guy | Mock, Beverly A. | Mogil, Jeffrey S. | Montagutelli, Xavier | Morahan, Grant | Mountz, John D. | Nagase, Hiroki | Nowakowski, Richard S. | O’hara, Bruce F. | Osadchuk, Alexander V. | Paigen, Beverly | Palmer, Abraham A. | Peirce, Jeremy L. | Pomp, Daniel | Rosemann, Michael | Rosen, Glenn D. | Schalkwyk, Leonard C. | Seltzer, Ze’ev | Settle, Stephen | Shimomura, Kazuhiro | Shou, Siming | Sikela, James M. | Siracusa, Linda D. | Spearow, Jimmy L. | Teuscher, Cory | Threadgill, David W. | Toth, Linda A. | Toye, Ayo A. | Vadasz, Csaba | Zant, Gary Van | Wakeland, Edward | Williams, Robert W. | Zhang, Huang-Ge | Zou, Fei

Edité par CCSD ; Nature Publishing Group -

International audience. This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?

Suggestions

Du même auteur

Impact of Genetic Variation on Stress‐Related Ethanol Consumption

Archive ouverte | Mulligan, Megan K. | CCSD

International audience. Background The effect of stress on alcohol consumption in humans is highly variable, and the underlying processes are not yet understood. Attempts to model a positive relationship between str...

Exploring the involvement of Tac2 in the mouse hippocampal stress response through gene networking

Archive ouverte | Hook, Mike | CCSD

International audience. Tachykinin 2 (Tac2) is expressed in a number of areas throughout the brain, including the hippocampus. However, knowledge about its function has been only well explored in the hypothalamus in...

Genetic Contribution to Initial and Progressive Alcohol Intake Among Recombinant Inbred Strains of Mice

Archive ouverte | Mulligan, Megan K. | CCSD

International audience. We profiled individual differences in alcohol consumption upon initial exposure and during 5 weeks of voluntary alcohol intake in female mice from 39 BXD recombinant inbred strains and parent...

Chargement des enrichissements...