Afficher la couverture 'Bolaamphiphile-based supramolecular gels with drugs eliciting membrane effects | Latxague, Laurent' en grand format
/5

0 avis

Bolaamphiphile-based supramolecular gels with drugs eliciting membrane effects

Archive ouverte

Latxague, Laurent | Benizri, Sébastien | Gaubert, Alexandra | Tolchard, James | Martinez, Denis | Morvan, Estelle | Grélard, Axelle | Saad, Ahmad | Habenstein, Birgit | Loquet, Antoine | Barthélémy, Philippe

Edité par CCSD ; Elsevier -

International audience. Supramolecular chemistry has garnered important interest in recent years toward improving therapeutic efficacy via drug delivery approaches. Although self-assemblies have been deeply investigated, the design of novel drugs leveraging supramolecular chemistry is less known. In this contribution, we show that a Low Molecular Weight Gel (LMWG) can elicit cancer cell apoptosis. This biological effect results from the unique supramolecular properties of a bolaamphiphile-based gelator, which allow for strong interaction with the lipid membrane. This novel supramolecular-drug paradigm opens up new possibilities for therapeutic applications targeting membrane lipids.

Suggestions

Du même auteur

Structures of Pathological and Functional Amyloids and Prions, a Solid-State NMR Perspective

Archive ouverte | Daskalov, Asen | CCSD

International audience. Infectious proteins or prions are a remarkable class of pathogens, where pathogenicity and infectious state correspond to conformational transition of a protein fold. The conformational chang...

Structural dissection of amyloid aggregates of TDP-43 and its C-terminal fragments TDP-35 and TDP-16

Archive ouverte | Shenoy K P, Jayakrishna | CCSD

International audience. The TAR DNA-binding protein (TDP-43) self-assembles into prion-like aggregates considered to be the structural hallmark of amyotrophic lateral sclerosis and frontotemporal dementia. Here we u...

Structural polymorphism of the low-complexity C-terminal domain of TDP-43 amyloid aggregates revealed by solid-state NMR

Archive ouverte | Shenoy, Jayakrishna | CCSD

International audience. Aberrant aggregation of the transactive response DNA-binding protein (TDP-43) is associated with several lethal neurodegenerative diseases, including amyotrophic lateral sclerosis and frontot...

Chargement des enrichissements...