Afficher la couverture 'Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad | Chawech, Rachid' en grand format
/5

0 avis

Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad

Archive ouverte

Chawech, Rachid | Jarraya, Raoudha | Girardi, Cynthia | Vansteelandt, Marieke | Marti, Guillaume | Nasri, Imen | Racaud-Sultan, Claire | Fabre, Nicolas

Edité par CCSD ; MDPI -

International audience. Two new tetracyclic cucurbitane-type triterpene glycosides were isolated from an ethyl acetate extract of Citrullus colocynthis leaves together with four known cucurbitacins. Their structures were established on the basis of their spectroscopic data (mainly NMR and mass spectrometry). Evaluation of the in vitro cytotoxic activity of the isolated compounds against two human colon cancer cell lines (HT29 and Caco-2) and one normal rat intestine epithelial cell line (IEC6), revealed that one of the isolated compounds presented interesting specific cytotoxic activity towards colorectal cell lines.

Suggestions

Du même auteur

Anti-inflammatory and anticancer effects of flavonol glycosides from Diplotaxis harra through GSK3β regulation in intestinal cells

Archive ouverte | Nasri, Imen | CCSD

International audience. Context and objective: Diplotaxis harra (Forssk.) Boiss. (Brassicaceae) is traditionally used as an antidiabetic, anti-inflammatory or anticancer agent. In these pathologies, the glycogen syn...

Hammada scoparia flavonoids and rutin kill adherent and chemoresistant leukemic cells

Archive ouverte | Bourogaa, Ezzeddine | CCSD

International audience. In search for compounds able to reduce cell adhesion-mediated drug resistance (CAM-DR), we studied effects of Hammada scoparia extracts on leukemic cells adherent or in suspension. We show th...

Analysis and fragmentation mechanisms of hirsutinolide-type sesquiterpene lactones by ultra-high-performance liquid chromatography/electrospray ionization linear ion trap Orbitrap mass spectrometry

Archive ouverte | Girardi, Cynthia | CCSD

International audience. Rationale: Hirsutinolide-type sesquiterpene lactones (SLs) are natural biologically active compounds mainly found in the genus Vernonia. Very few studies have been published about the fragmen...

Chargement des enrichissements...