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Choroidal Thickness, Vascular Factors, And Age-Related Macular Degeneration: The Alienor Study. : Retina
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Edité par CCSD ; Lippincott, Williams & Wilkins -
International audience. PURPOSE: To study the associations of subfoveal choroidal thickness with vascular risk factors and age-related macular degeneration. METHODS: Two hundred sixty-one participants of the Alienor study had gradable enhanced-depth imaging optical coherence tomography scans of the macula and available data on vascular and genetic risk factors (assessed through face-to-face interview and fasting blood samples) and age-related macular degeneration status (assessed from retinal photographs and optical coherence tomography). Subfoveal choroidal thickness was measured manually on one horizontal scan passing through the fovea. RESULTS: In a multivariate mixed linear model, subfoveal choroidal thickness was independently associated with age greater than 80 years (-21.77 mum, P = 0.02), axial length (-21.77 mum, P < 0.0001), heavy smoking (>/=20 pack-years: -24.89 mum, P = 0.05), fasting blood glucose higher than 7 mmol/L (-53.17 mum, P = 0.02), and lipid-lowering treatment (+18.23, P = 0.047). After multivariate adjustment for age, sex, axial length, and vascular and genetic risk factors, subfoveal choroidal thickness was thinner in eyes with central hyperpigmentation (-45.39 mum, P = 0.006), central hypopigmentation (-44.99 mum, P = 0.001), and central pigmentary abnormalities (-44.50 mum, P = 0.001), but not in eyes with late age-related macular degeneration (-18.05 mum, P = 0.33) or soft drusen. CONCLUSION: These findings indicate a relationship between vascular risk factors and choroidal thinning and suggest an early involvement of the choroid in the pathogenesis of age-related macular degeneration.
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